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In secnidazole for bv further embodiment, R 7 is phenyl substituted at the 5 position (of the phenyl ring) with an alkyl substituted amino methyl group (eg, (—CH 2—N(CH 3) 2, —CH 2—NH—CH(CH 3) 2, —CH 2—N(CH 3)—CH(CH 3) 2, —CH 2—N-piperdinyl), —CH 2NH—CH 3, —CH 2—NH-cyclopropyl, CH 2—NH-t-butyl, —CH 2—N(CH 3)-benzyl, —CH 2—N(CH 3)—CH 2—CH═CH 2, CH 2—NH—(CH 2) 2—CF 3, CH 2—NH—CH 2—C(═O)—NH 2, or —CH 2—NH-cyclohexyl,). The substituted tetracycline compounds of the invention have been found to be particularly effective for modulation of transcription and may be used in applications for regulation of transcription of genes or gene products known in the secnidazole single dose

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