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Suppressive acyclovir therapy (800–1200 mg/day in 3 or 4 doses) administered for several weeks prior to the expected date of delivery reduced the frequency of symptomatic HSV recurrences at the time of labor and the requirement for genital herpes-related cesarean sections in several small studies [ 8–10].

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In secnidazole for bv further embodiment, R 7 is phenyl substituted at the 5 position (of the phenyl ring) with an alkyl substituted amino methyl group (eg, (—CH 2—N(CH 3) 2, —CH 2—NH—CH(CH 3) 2, —CH 2—N(CH 3)—CH(CH 3) 2, —CH 2—N-piperdinyl), —CH 2NH—CH 3, —CH 2—NH-cyclopropyl, CH 2—NH-t-butyl, —CH 2—N(CH 3)-benzyl, —CH 2—N(CH 3)—CH 2—CH═CH 2, CH 2—NH—(CH 2) 2—CF 3, CH 2—NH—CH 2—C(═O)—NH 2, or —CH 2—NH-cyclohexyl,). The substituted tetracycline compounds of the invention have been found to be particularly effective for modulation of transcription and may be used in applications for regulation of transcription of genes or gene products known in the secnidazole single dose

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