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An endogenous gene having tetO sequences inserted into a non-critical regulatory region will retain the ability to be expressed in its normal constitutive and/or tissue-specific manner but, additionally, can be downregulated by a substituted tetracycline compound-controlled transcriptional silencer protein in a controlled manner.

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I've spoken with thousands of men and women over the last decade who describe a variety of symptoms that their doctor has not been able to help them eliminate.

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